Understanding and Reversing Antimicrobial Resistance
Reversing resistance with efflux pump inhibitors
The main cause of multidrug resistance is the presence of drug efflux pumps, which remove antibiotics from the bacterial cell. We are using our expertise on these efflux pumps to develop inhibitors that are reversing resistance and restoring antibiotic activity in some of the most critically dangerous and drug resistant pathogens.
Combatting antimicrobial resistance through targeting bacterial cell division
This project aims to develop novel antibiotics targeted to the bacterial cell-division protein, FtsZ.
Understanding the development and dissemination of AMR in RACFs
This project investigates the risks factors contributing to the development of antimicrobial drug resistance in residential age care facilities.
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