Understanding and Reversing Antimicrobial Resistance

Antimicrobial resistance is one of the greatest threats to society today. Unless urgent action is taken, 10 million deaths due to antibiotic resistant infections will occur each year by 2050 and antibiotic resistant infections will be the major cause of human mortality. Yet, antibiotic drug discovery and development has all but ground to a halt and demand far outpaces provision. New antibacterials, with novel mechanisms of action, are urgently required to meet existing and future treatment needs arising from drug resistance. Our work is aimed to understanding antimicrobial resistance as a basis for antimicrobial drug discovery.

Reversing resistance with efflux pump inhibitors

The main cause of multidrug resistance is the presence of drug efflux pumps, which remove antibiotics from the bacterial cell. We are using our expertise on these efflux pumps to develop inhibitors that are reversing resistance and restoring antibiotic activity in some of the most critically dangerous and drug resistant pathogens.

Combatting antimicrobial resistance through targeting bacterial cell division

This project aims to develop novel antibiotics targeted to the bacterial cell-division protein, FtsZ.

Understanding the development and dissemination of AMR in RACFs

This project investigates the risks factors contributing to the development of antimicrobial drug resistance in residential age care facilities.