Antimicrobial resistance is one of the greatest threats to society today. Unless urgent action is taken, 10 million deaths due to antibiotic resistant infections will occur each year by 2050 and antibiotic resistant infections will be the major cause of human mortality. Yet, antibiotic drug discovery and development has all but ground to a halt and demand far outpaces provision. New antibacterials, with novel mechanisms of action, are urgently required to meet existing and future treatment needs arising from drug resistance. Our work is aimed to understanding antimicrobial resistance as a basis for antimicrobial drug discovery.